Leveraging the data from existing, longitudinal cohorts helps to support approaches that can evolve with the science. ECHO capitalizes on the growing number of clinical research networks and technological breakthroughs in pediatric research to investigate the effects of a broad range of early environmental exposures — including physical, chemical, biological, social, behavioral, natural and built environments — on child health and development.
ECHO cohorts will look at existing data to test and analyze their project's hypotheses. These hypotheses prioritize the five key pediatric outcomes that have a high public health impact:
- Pre-, Peri-, and Postnatal
- Child Obesity
- Positive Health
Other areas of focus include policies and practices—for data sharing, harmonization, and analysis; use of biospecimens; publications; and engagement—that will drive best practices for conducting Team Science in the 21st century.
The ECHO Coordinating Center is the central site responsible for organizing and managing activities and logistics for all collaborative components of the initiative, including oversight and coordination of the multi-cohort study design, evaluation of the process, and tissue sample storage.
The ECHO Children's Health and Exposure Analysis Resource (CHEAR) Core serves as a consortium resource for laboratory and statistical analyses of personal environmental exposures in existing and future collections of biological samples.